Molecular Formula | C11H10N2O2S |
Molar Mass | 234.27 |
Density | 1.39±0.1 g/cm3(Predicted) |
Boling Point | 468.1±35.0 °C(Predicted) |
Solubility | Soluble in DMSO (up to 60 mg/ml) or in Ethanol (up to 16 mg/ml). |
Appearance | solid |
Color | Tan |
pKa | 13.60±0.20(Predicted) |
Storage Condition | -20° |
Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months. |
In vitro study | In NSPCs, isoxazole 9 increases cell number and promotes cell differentiation. In OPCs, isoxazole 9 induces cell damage. In growing EPCs, isoxazole 9 reduced microtubule formation without affecting early EPCs. |
In vivo study | In mice, isoxazole 9 (20 mg/kg, I. p.) crossing the blood-brain barrier and increasing neural stem cell proliferation and neurogenesis in hippocampal SGZ by a mef2-specific mechanism. Ioxazole 9 (20 mg/kg, I. p.) also increased the differentiation and dendritic complexity of immature neurons and improved memory. In MWM, isoxazole 9 improves spatial memory. |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 4.269 ml | 21.343 ml | 42.686 ml |
5 mM | 0.854 ml | 4.269 ml | 8.537 ml |
10 mM | 0.427 ml | 2.134 ml | 4.269 ml |
5 mM | 0.085 ml | 0.427 ml | 0.854 ml |
biological activity | Isoxazole 9 (Isx-9) is a synthetic promoter of adult neurogenesis, they act by inducing neuronal differentiation of mature neural stem/precursor cells (NSPCs). Isoxazole 9 (Isx-9) can activate multiple signaling pathways, including TGF-β induced epithelial-mesenchymal transition signaling pathway (EMT), canonical and non-canonical Wnt signaling pathways at different stages of cardiac differentiation. |